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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of research design, like recruitment and consent in adherence, as well as the use of commonly available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from different geographical regions. This kind of heterogeneity is necessary for 프라그마틱 슬롯버프 practical trials to be valid, and it also reduces the chance of bias in the results. However, too much heterogeneity could cause issues with the trial design.

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The aim of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are typically requested by practitioners and policymakers to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention and its results. They should, however, not be used to replace the need for explanation studies.

The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis, and pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study that includes recruitment, design, implementation of the intervention, and follow-up.

There is a growing increase in the number of pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.